- A Case of the McCune: Albright Syndrome Associated with Activating Mutations of Stimulatory G Protein.
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Phil Ho Chung, Jung Kyu Whang, Youn Yee Kim, Ji Ju Whang, Chan Moon Park, Chang Hoon Yim, Ho Yeun Chung, Ki Ok Han, Hak Chul Jang, Hyun Koo Yoon, Hun Ki Min, Sung Ran Hong, Young Soon Kang, In Gul Moon, In Kwon Han
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J Korean Endocr Soc. 1999;14(4):779-785. Published online January 1, 2001
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- McCune-Albright syndrome (MAS) is a sporadic disease classically including polyostotic fibrous dysplasia, cafe -au-lait spots, sexual precocity, and other hyperfunctional endocrinopathies. Recent investigations suggest an etiological role for activating embryonic somatic missense mutations in the gene for the a subunit of Gs (Gsa), the G protein that stimulates adenylyl cyclase. DNA from bone, ovary, and blood was analyzed by using polymerase chain reaction and sequenced. A embryological somatic mutation of Gsa gene encoding substitution of a Cys for Arg at amino acid 201 from cells of dysplastic bone and ovary was observed, and the distribution of mutant gene reveals mosaic pattern. We report a case of McCune-Albright syndrome with an activating mutation at codon 201 of Gsa subunit on ovary and bone tissue that was experienced recently.
- Serum Fluoride Level in Normal Adult Women and Changes in Serum Fluoride Level after Disodium Monofluorophosphate Administration.
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Hyun Koo Yoon, Mi Sun Jung, In Kul Moon, Sang Woo Kim, Ho Yeon Chung, Ki Ok Han, Hak Chul Jang, In Kwon Han, Hun Ki Min
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J Korean Endocr Soc. 1997;12(4):565-570. Published online January 1, 2001
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- BACKGROUND
Since the morning fluoride level of 10 uM is recommended for adults patients being treated for osteoporosis so far, measurement of serum fluoride level is important to detect abnormally high levels or to detect levels below the therapeutic windows. Aims of this study are to determine the normal range of serum ionic fluoride levels in Korean female adults (from 5th to 7th decade), and to evaluate the in vivo fluoride pharmacokinetics of monofluorophosphate in Korean adults. METHODS: Serum level of fluoride was measured from blood samples of 72 female subjects (age 43-69years) using an ion selective electrode. For pharrnacokinetics of monofluorophosphate-calcium (MFP-Ca), 6 subjects (age 27~45 years) were included to be withdrawn the blood hourly for the first S hours and the blood was withdrawn at 24 hours after a single dose of MFP-Ca. RESULTS: Mean level of serum fluoride was 1.64+-0.12uM in 5th, 6th, 7th decades adults, and there was no difference of serum fluoride levels among age groups. Peak serum fluoride level exhibited 5.02+-0.67pM, and returned to basal level on 24 hours after a single dose of MFP-Ca. CONCLUSION: This study shows that mean serutn fluoride of Korean female adults (from 5th to 7th decade) is not different from that of other reports, and a single dose of MFP-Ca does not cause serum fluoride levels above the recommended therapeutic windows of 5-10uM for 24 hours.
- Non-association of Pvull and Xval Estrogen receptor Genotypes with Bone Mineral Density and Bone Markers in Korean Premenopausal Women.
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Hyun Koo Yoon, Ho Yeon Chung, In Gul Moon, Chang Hoon Yim, Sang Woo Kim, Ki Ok Han, In Kwon Han, Hun Ki Min, Dong Won Suh, Dong Hee Cho, Bo Kyung Park, Jong Tae Choi
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J Korean Endocr Soc. 1997;12(2):207-214. Published online January 1, 2001
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- BACKGROUND
Bone mineral density (BMD) is under strong genetic control. A recently reported case of severe estrogen resistance caused by a germ-line mutation at the estrogen receptor gene locus suggests the possibility that other variants of the estrogen receptor (ER) gene could be responsible for the heritable components of bone density. METHODS: Two restriction fragment length polymorphisms (RFLPs) at the ER gene locus, represented as PvuII and XbaI, and their relationship to bone mineral density (BMD) and bone turnover markers were examined in 95 healthy premenopausal women. Their mean age was 29 +-6.9 years (mean+-SD). RESULTS: The distribution of the PvuII and XbaI RFLPs was as follows: PP 20 (21.1%), Pp 40 (42.1%), pp 35 (36.8%), and XX 5 (5.3%), Xx 33 (34.7%), xx 57 (60.0%) (capital letters signify the absence of, and lower case letters signify the presence of the restriction site of each RFLP). There was no significant relation between ER genotypes and BMD measured at several sites such as lumbar spine (L2-4), distal forearm, and femoral neck. Also no significant genotypic differences were found in the several biochemical markers and sex hormone status. CONCLUSION: These data indicate that these polymorphisms are not predietive of bone turnover nor BMD in a sample of healthy Korean premenopausal women.
- Effect of Antiliyolytic Agents on Glueose Metabolism in Thyrotoxic Patients.
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Seong Yeon Kim, Kyung Soo Park, Bo Youn Cho, Hong Kyu Lee, Chan Soo Shin, Chang Soon Koh, Hun Ki Min, Tae Geun Oh, Chul Hee Kim, Moon Kyu Lee, Jong Ho Ahn, Kee Up Lee
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J Korean Endocr Soc. 1994;9(4):325-331. Published online November 6, 2019
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- Decreased glucose tolerance is often found in patients with thyrotoxicosis but the pathogenetic mechanisms are poorly understood. Since the concentrations of free fatty acid are usually elevated due to increased lipolysis in thyrotoxicosis, the preferential oxidation of the free fatty acids may explain the decreased glucose tolerance in hyperthyroidism. The aim of this study was to investigate whether lowering plasma free fatty acid(FFA) by acipimox, a long-acting antilipolytic agent, could affect glucose metabolism in thyrotoxicosis. We performed intravenous glucose tolerance test with acipimox or placebo in 6 untreated thyrotoxicmen and 6 age-and body mass index(BMI)-matched controls. The following results were obtained.1) The basal plasma FFA concentration in thyrotoxic patients were significantly higher than those in controls(997.0+-303.4 uEq/L vs. 290.5+-169.1 uEq/L; p<0.01). 2) Plasma FFA concentrations decreased rapidly with acipimox ingestion in both controls and thyrotoxic patients.3) Plasma glucose concentrations were significantly lower with acipimox ingestion than with placebo in thyrotoxic patients from 17min after intravenous glucose load and to the end of the study.4) Plasma insulin concentrations in thyrotoxic patients with acipimox ingestion were higher at 5, 7 min after iv glucose load.5) In thyrotoxic patients, glucose disappearance rate(K_glucose) in acipimox treatment was significantly higher than that in placebo treatment(2.44+-0.84 vs. 1.58+-0.37;p<0.05). 6) K_glucose values were inversely correlated with basal FFA concentrations(r=-0.58, p<0.05). In summary, in thyrotoxic patients with elevated plasma FFA levels, acipimox lowered plasma FFA, which in turn improved glucose tolerance.
- A Clinical study on the diagnesis and Treatment of Cushing's Disease - The significance of bilateral inferior petrosal sinus sampling -.
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Seong Yeon Kim, Kyung Soo Park, Bo Youn Cho, Hong Kyu Lee, Jae Seok Jeon, Hyeong Kyu Park, Chang Soon Koh, Hun Ki Min, Heu Won Jeong, Dae Hee Han, Moon Hee Han, Kee Hyun Jang
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J Korean Endocr Soc. 1994;9(2):115-120. Published online November 6, 2019
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- Bilateral inferior petrosal sinus sampling(IPSS) is known to be useful for the differential diagnosis of ACTH-dependent Cushing's syndrome and for the preoperative localization of pituitary microadenomas.To evaluate the usefulness of IPSS, we performed the procedure in the 17 cases of ACTH-dependent Cushing's syndrome including 2 cases of macroadenomas, 6 of them with CRH stimulation test. A inferior petrosal sinus-to-peripheral ACTH ratio of 2:1 or greater(3:1 after CRH stimulation) indicates a pituitary source of ACTH hypersecretion, and a ratio of the ACTH level in one inferior petrosal sinus to the ACTH level in the other of 1:4 or greater lateralizes the microadenomas to that half of the pituitary gland.With these criteria, we diagnosed Cushing's disease in 15 of 17 cases of ACTH-dependent Cushing's syndrome, and localized the lesion in 8 of 13 cases of microadenoma.In conclusion, IPSS with CRH stimulation has high diagnostic accuracy in the differential diagnosis of ACTH-dependent Cushing's syndrome, but still has the limitations on the localization of microadenoma.
- Preoperative treatment of acromegaly with long-acting somatostatin analog octreotide.
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Seok In Lee, Hyun Kyu Kim, Kyung Soo Ko, Kyong Soo Park, Seong Yeon Kim, Bo Youn Cho, Hong Kyu Lee, Chang Soon Koh, Hun Ki Min, Hyun Jip Kim, Heu Won Jeong, Dae Hee Han
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J Korean Endocr Soc. 1993;8(1):35-41. Published online January 1, 2001
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- No abstract available.
- Combined estrogen-progesterone(Divina@) treatment in postmenopausal women with special reference to serum lipoprotein patterns.
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Min Seon Kim, Tae Geun Oh, Kyung Soo Ko, Kyong Soo Park, Seong Yeon Kim, Hong Kyu Lee, Chang Soon Koh, Hun Ki Min, Hak Chul Jang, Yong Ki Min, In Kwon Han
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J Korean Endocr Soc. 1992;7(3):267-272. Published online January 1, 2001
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- No abstract available.
- Effect of prolactin on aldosterone secretion in humans.
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Yun Ah Sung, Seong Yeon Kim, Bo Youn Cho, Hong Kyu Lee, Chang Soon Koh, Hun Ki Min, Seung Keun Oh
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J Korean Endocr Soc. 1992;7(2):136-142. Published online January 1, 2001
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- No abstract available.
- Clinical features of autonomously functioning thyroid nodules.
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Min Ho Shong, Jun Key Chung, Seong Yeon Kim, Myung Chul Lee, Bo Youn Cho, Hong Kyu Lee, Chang Soon Koh, Hun Ki Min
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J Korean Endocr Soc. 1992;7(2):115-120. Published online January 1, 2001
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- No abstract available.
- Parathyroid imaging: comparison of technetium-thallium subtraction scan, ultrasonography and computed tomography.
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Yong Soo Park, Suk In Lee, Seong Yeon Kim, Myung Chul Lee, Bo Youn Cho, Hong Kyu Lee, Chang Soon Koh, Hun Ki Min, Sung Keun Oh, Chai Hyung Park, Myung Shik Lee
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J Korean Endocr Soc. 1992;7(1):52-60. Published online January 1, 2001
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- No abstract available.
- Induction of puberty and spermatogenesis by pulsatile gonadotropin releasing hormone(GnRH) therapy in men with isolated hypogonadotro- pic hypogonadism(IHH) with or without anosmia.
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Yong Soo Park, Kyung Soo Ko, Kyong Soo Park, Seong Yeun Kim, Bo Youn Cho, Hong Kyu Lee, Chang Soon Koh, Hun Ki Min, Ryoung Doo Rhee, Hak Chul Chang
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J Korean Endocr Soc. 1991;6(4):332-341. Published online January 1, 2001
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- No abstract available.
- Amiodarone-induced thyrotoxicosis.
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Min Ho Shong, Ka Hee Yi, Seong Yeon Kim, Bo Youn Cho, Hong Kyu Lee, Chang Soon Koh, Hun Ki Min
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J Korean Endocr Soc. 1991;6(3):276-279. Published online January 1, 2001
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- No abstract available.
- Changes in diurnal variation of thyrotropin secretion in nonthyroid- al illness and its mechanism.
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Bo Youn Cho, Min Ho Shong, Ka Hee Yi, Jae Joon Koh, Kyung Soo Ko, Kyoung Soo Park, Seong Yeon Kim, Hong Kyu Lee, Chang Soon Koh, Hun Ki Min
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J Korean Endocr Soc. 1991;6(2):133-140. Published online January 1, 2001
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- No abstract available.
- Primary hypothyroidism following Graves' disease.
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Min Ho Shong, Ka Hee Yi, Bo Youn Cho, Hong Kyu Lee, Chang Soon Koh, Hun Ki Min
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J Korean Endocr Soc. 1991;6(1):68-74. Published online January 1, 2001
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- No abstract available.
- Changes of blood pressure and RBC membrane Na+ transport in thyroid disease.
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Won Bae Kim, Kyung Soo Ko, Suk In Lee, Seong Yeon Kim, Bo Yeon Cho, Hong Kyu Lee, Chang Soon Koh, Hun Ki Min
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J Korean Endocr Soc. 1991;6(1):25-37. Published online January 1, 2001
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- No abstract available.
- Mechanisms of action on blocking type-thyrotropin receptor antibody.
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Bo Youn Cho, Dong Soo Lee, Ka Hee Yi, Hong Kyu Lee, Chang Soon Koh, Hun Ki Min, Young Kee Shong
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J Korean Endocr Soc. 1991;6(1):8-16. Published online January 1, 2001
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- No abstract available.
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